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KMID : 1134820230520090897
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Journal of the Korean Society of Food Science and Nutrition
2023 Volume.52 No. 9 p.897 ~ p.906
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In vitro and In vivo Evaluation for Hangover Relief: Effect of Lactobacillus fermentum HDB1098 on Acetaldehyde Production
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Yun Min-Kyu
Cho Hyun-Ju
In Jung-Hoon
Lee Chang-Wan
Song Ji-Won
Kim Du-Seong
Lee Seung-Hun
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Abstract
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This study evaluates the pharmacological effects of Lactobacillus fermentum HDB1098 against acetaldehyde-induced hepatotoxicity in vitro and acetaldehyde decomposition in vivo. L. fermentum HDB1098 markedly prevented and mitigated acetaldehyde-induced cytotoxicity and cell death in HepG2 cells via down-regulation of pro-inflammatory cytokines (TNF-α, IL-1β) and up-regulation of anti-inflammatory cytokine (IL-10) mRNA expressions. Furthermore, L. fermentum HDB1098 significantly increased the hepatic acetaldehyde dehydrogenase activity and reduced blood acetaldehyde concentration in alcohol-fed Sprague Dawley rats. These results demonstrate that L. fermentum HDB1098 is a potential new health-beneficial candidate that triggers acetaldehyde decomposition and regulates acetaldehyde-induced inflammation in the liver, thereby relieving hangover symptoms.
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KEYWORD
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Lactobacillus fermentum, acetaldehyde, cell cytotoxicity, cell survival, hangover
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